Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses
S. Ndeupen, A. Bouteau, C. Herbst, Z. Qin, Z. Hutchins, D. Kurup, L. Z. Diba, B. Igyarto
This study shows that Langerhans cells and cDC1s have redundant roles in mRNA-LNP-induced anti-influenza and anti-SARS-CoV-2 immunity, with IL-6 driving Tfh and humoral responses independently of neutrophils.
bioRxiv · Aug 1, 2021Immunology