Z. Qin

An automated archival single-nucleus total RNA sequencing platform mapping integrative and retrospective cell atlas of gliomas

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

This study uses plasmonic nanovesicles to measure diffusion in GBM and finds the tumor margin has the lowest diffusion coefficient, indicating it acts as a diffusion barrier.

AI in Paleontology

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency by Siphoning Material From Neighboring Cells Using Intracellular Monitoring - a Novel Mechanism of Antigen Acquisition

Dendritic cells maintain RNA and protein levels for conditionally deleted genes by siphoning material from neighboring cells using a novel mechanism.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

Protein language model-based end-to-end type II polyketide prediction without sequence alignment

This study introduces DeepT2, a machine learning model that predicts type II polyketides from KS{beta} sequences without alignment, using NLP techniques and metagenomics/metabolomics data.

Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

This study uses intravital microscopy to examine satellite cell dynamics and interactions with myeloid cells during skeletal muscle regeneration, revealing that direct contact is not required for early activation but is important for proliferation and differentiation.

Structure of the Native Chemotaxis Core Signalling Unit from E-gene lysed E. coli cells

The paper presents the structure of the chemotaxis core signaling unit from E. coli cells using cryo-electron tomography and predicts atomic structures using AlphaFold2.

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

Significantly amplified photoacoustic effect for silica-coated gold nanoparticles by interface heat transfer mechanisms

This study demonstrates a 4-fold photoacoustic amplification in silica-coated gold nanoparticles using picosecond laser excitation, attributed to interface heat transfer mechanisms.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

Optical Control Of Neuronal Activities With Photoswitchable Nanovesicles

This paper develops photoswitchable nanovesicles (azosomes) for precise optical control of molecular release in neurons, demonstrating their ability to activate dopamine receptors in cultured striatal neurons.

Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

Calcium-Mediated Modulation of Blood-Brain Barrier Permeability by Laser Stimulation of Endothelial-Targeted Nanoparticles

This study investigates how laser stimulation of endothelial-targeted nanoparticles increases blood-brain barrier permeability through calcium signaling and cytoskeletal changes.

Shell Microelectrode Arrays (MEAs) for brain organoids

This paper develops shell microelectrode arrays (MEAs) for brain organoids, enabling long-term electrophysiology recording from 3D organoids.

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

This study investigates the long-term immunological effects of pre-exposure to mRNA-LNP vaccines, finding both inhibition of adaptive immunity and altered innate immune fitness that can be inherited.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

Single Pulse Heating of Nanoparticle Array for Biological Applications

This study develops a computational model to investigate single-pulsed nanoparticle array heating and its effects on protein denaturation and activation, identifying key parameters for targeted protein manipulation.

Direct focus sensing and shaping for high-resolution multi-photon imaging in deep tissue

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses

This study shows that Langerhans cells and cDC1s have redundant roles in mRNA-LNP-induced anti-influenza and anti-SARS-CoV-2 immunity, with IL-6 driving Tfh and humoral responses independently of neutrophils.

Nanoparticle fragmentation at solid state under single picosecond laser pulse stimulation

This study shows that picosecond laser pulses cause gold nanoparticle fragmentation that differs from known mechanisms, occurring below melting point and producing a bimodal size distribution.

Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

This study shows that lipid nanoparticles used in preclinical mRNA vaccine studies are highly inflammatory in mice, leading to severe side effects similar to those observed in humans.

SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus

This study shows that SARS-CoV-2 proteins and anti-COVID-19 drugs can reactivate KSHV, increasing cancer risk in infected patients.

Refactoring the formicamycin biosynthetic gene cluster to make high-level producing strains and new molecules

This paper refactors the formicamycin biosynthetic gene cluster to enhance production and generate new molecules by manipulating regulatory elements.

Computational investigation of protein photoinactivation by molecular hyperthermia

This study uses a numerical model to investigate parameters affecting protein inactivation via molecular hyperthermia, identifying key factors that influence the impact zone of nanoscale heating.

The effect of a novel powerful ABA mimic on the improvement of color in grapes and its mechanism

This study shows that iso-PhABA improves grape color and anthocyanin content more than ABA by enhancing enzyme activity and receptor affinity.

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

Schistosoma Japonicum infection in Treg-specific USP21 knock-out mice

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.