A. Bouteau

Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency by Siphoning Material From Neighboring Cells Using Intracellular Monitoring - a Novel Mechanism of Antigen Acquisition

Dendritic cells maintain RNA and protein levels for conditionally deleted genes by siphoning material from neighboring cells using a novel mechanism.

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

This study investigates the long-term immunological effects of pre-exposure to mRNA-LNP vaccines, finding both inhibition of adaptive immunity and altered innate immune fitness that can be inherited.

Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses

This study shows that Langerhans cells and cDC1s have redundant roles in mRNA-LNP-induced anti-influenza and anti-SARS-CoV-2 immunity, with IL-6 driving Tfh and humoral responses independently of neutrophils.

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

This study shows that lipid nanoparticles used in preclinical mRNA vaccine studies are highly inflammatory in mice, leading to severe side effects similar to those observed in humans.

Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

This study shows that long-term absence of Langerhans cells alters gene expression in keratinocytes and dendritic epidermal T cells, suggesting immune cells influence tissue homeostasis.