The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
S. Ndeupen, Z. Qin, S. Jacobsen, H. Estanbouli, A. Bouteau, B. Z. Igyarto
This study shows that lipid nanoparticles used in preclinical mRNA vaccine studies are highly inflammatory in mice, leading to severe side effects similar to those observed in humans.
bioRxiv · Mar 4, 2021Immunology