Suppression of epileptic seizures by transcranial activation of K+-selective channelrhodopsin
Xiaodong Duan, Chong Zhang, Yujie Wu, Jun Ju, Zhe Xu, Xuanyi Li, Yao Liu, S. Ohdah, Oana M. Constantin, Yifan Pan, Zhonghua Lu, Cheng Wang, Xiaojing Chen, Christine E. Gee, Georg Nagel, , Kun Song
This study develops a K+-selective channelrhodopsin for transcranial optogenetic inhibition of neuronal activity, showing reduced seizure activity in mouse models.
Nature Communications · Jan 9, 2025Peer-reviewedNeuroscience