Zhonghua Lu

This paper introduces a biointegrated living brain stimulator that uses dopamine neurotransmitter-evoked signaling to restore motor function in a rodent Parkinson's disease model.

This paper introduces RECODE, a system that improves RNA editing specificity by using gRNA-regulated ADAR1 deaminase stability, achieving high editing efficiency for a FUS mutation.

This study shows that negatively charged α-Synuclein condensates influence molecular partitioning based on charge differences, revealing electrostatic effects on phase separation.

This study develops a K+-selective channelrhodopsin for transcranial optogenetic inhibition of neuronal activity, showing reduced seizure activity in mouse models.

The paper shows that disrupting activity in specific dopaminergic neurons during memory consolidation impairs long-term memory and causes sleep fragmentation in Drosophila.

This paper develops a new genetically encoded fluorescent cAMP indicator, G-Flamp1, which shows high sensitivity, brightness, and fast response kinetics for in vivo cAMP imaging.

This study shows that D2 dopamine receptors in the superior colliculus modulate defensive behaviors to visual threats, with optogenetic activation promoting defensive responses and chemogenetic inhibition reducing them.

In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.