Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival During Cancer Cachexia Syndrome
F. Henriques, M. Lopes, F. Franco, P. Knobl, K. Santos, L. Bueno, V. Correa, A. Bedard, A. Guilherme, A. Birbrair, S. Peres, S. Farmer, M. L. Batista
This study shows that disrupting TLR4 reduces adipose tissue remodeling and improves survival in cancer cachexia by inhibiting inflammation and macrophage infiltration.
bioRxiv · Aug 25, 2018Cancer Biology