Author

A. Guilherme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. Henriques· 4 shared M. Kelly· 3 shared M. P. Czech· 3 shared A. H. Bedard· 2 shared A. Bedard· 1 shared A. Birbrair· 1 shared A. Desai· 1 shared B. Yenilmez· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBioengineering

F. Henriques

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering

Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

F. Henriques, A. H. Bedard, A. Guilherme, M. Kelly, J. Chi, P. Zhang, L. M. Lifshitz, K. Bellve, L. Rowland, B. Yenilmez, S. Kumar, Y. Wang, J. Luban, L. S. Weinstein, J. D. Lin, , M. P. Czech

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

bioRxiv · May 4, 2020Physiology

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival During Cancer Cachexia Syndrome

F. Henriques, M. Lopes, F. Franco, P. Knobl, K. Santos, L. Bueno, V. Correa, A. Bedard, A. Guilherme, A. Birbrair, S. Peres, S. Farmer, M. L. Batista

This study shows that disrupting TLR4 reduces adipose tissue remodeling and improves survival in cancer cachexia by inhibiting inflammation and macrophage infiltration.

bioRxiv · Aug 25, 2018Cancer Biology

Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis

A. Guilherme, D. J. Pedersen, F. Henriques, A. H. Bedard, E. Henchey, M. Kelly, K. Rahmouni, D. A. Morgan, M. P. Czech

This study shows that white adipocyte lipogenesis influences brown adipose thermogenesis through neuronal signaling.

bioRxiv · May 16, 2018Cell Biology