Evolution avoids a pathological stabilizing interaction in the immune protein S100A9
J. L. Harman, P. N. Reardon, S. M. Costello, G. D. Warren, S. R. Phillips, P. J. Connor, S. Marqusee, M. J. Harms
The paper identifies a mutation in S100A9 that stabilizes a non-functional conformation, revealing an evolutionary constraint on stabilizing mutations.
bioRxiv · May 9, 2022 · PreprintBiophysics