Author

S. R. Shames

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

A. M. Joseph· 2 shared D. Chauhan· 2 shared T. Ngwaga· 2 shared A. E. Pohl· 1 shared A. G. Salberg· 1 shared A. J. Hydock· 1 shared A. M. Gilchrist· 1 shared B. V. Geisbrecht· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

A. M. Joseph

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Author profile →

5 papers

Recent·Most cited

Intrabacterial regulation of a cytotoxic effector by its cognate metaeffector promotes Legionella pneumophila virulence

D. Chauhan, A. M. Joseph, S. R. Shames

This study shows that MesI, a metaeffector of Legionella pneumophila, regulates the cytotoxic effector SidI within the bacterium, which is critical for virulence.

bioRxiv · Jun 12, 2022Microbiology

Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions

T. Ngwaga, D. Chauhan, A. G. Salberg, S. R. Shames

This study shows that the L. pneumophila effector LegC4 enhances host defense against the pathogen under inflammatory and oxidative stress by subverting the host proteasome activator PA28β.

bioRxiv · Dec 27, 2021 · PreprintMicrobiology

High-polyphenol extracts from Sorghum bicolor attenuate replication of Legionella pneumophila within RAW 264.7 macrophages

A. M. Gilchrist, D. Smolensky, S. Cox, R. Perumal, L. E. Noronha, S. R. Shames

This study shows that high-polyphenol extracts from Sorghum bicolor reduce L. pneumophila replication in macrophages via a novel mechanism distinct from tea polyphenols.

bioRxiv · Dec 19, 2019Microbiology

The Legionella pneumophila metaeffector Lpg2505 (SusF) regulates SidI-mediated translation inhibition and GDP-dependent glycosyltransferase activity.

A. M. Joseph, A. E. Pohl, T. J. Ball, T. G. Abram, D. K. Johnson, B. V. Geisbrecht, S. R. Shames

bioRxiv · Nov 16, 2019 · PreprintMicrobiology

The Dot/Icm-translocated effector LegC4 potentiates cytokine-mediated restriction of Legionella within accidental hosts.

T. Ngwaga, A. J. Hydock, S. Ganesan, S. R. Shames

This study shows that the Legionella effector LegC4 enhances cytokine-mediated restriction of Legionella replication in macrophages.

bioRxiv · Dec 11, 2018 · PreprintMicrobiology