Author

S. R. Simmons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. N. Bou Ghanem· 3 shared M. Bhalla· 3 shared A. Abamonte· 2 shared E. Y. I. Tchalla· 2 shared S. E. Herring· 2 shared A. P. Lenhard· 1 shared B. A. Pfeifer· 1 shared D. Park· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

E. N. Bou Ghanem

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3 papers

Recent·Most cited

Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection

S. R. Simmons, S. E. Herring, E. Y. I. Tchalla, A. P. Lenhard, M. Bhalla, E. N. Bou Ghanem

This study shows that activating A1 adenosine receptors in aged mice enhances early neutrophil recruitment to the lungs during Streptococcus pneumoniae infection, improving bacterial control.

bioRxiv · Jan 8, 2024 · PreprintImmunology

Liposomal encapsulation of polysaccharides (LEPS) as an effective vaccine strategy to protect aged hosts against S. pneumoniae infection

M. Bhalla, R. Nayerhoda, E. Y. I. Tchalla, A. Abamonte, D. Park, S. R. Simmons, B. A. Pfeifer, E. N. Bou Ghanem

This study evaluates a novel LEPS vaccine platform, showing it effectively protects aged mice against pneumococcal infections, with comparable antibody responses and improved function compared to Prevnar-13.

bioRxiv · Oct 18, 2021Microbiology

Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill S. pneumoniae

M. Bhalla, S. R. Simmons, A. Abamonte, S. E. Herring, S. E. Roggensack, E. N. Bou Ghanem

This study shows that adenosine signaling through A1 receptors improves neutrophil function in aged mice, reversing their reduced ability to kill pneumococcus.

bioRxiv · Apr 14, 2020Immunology