Author

S. E. Roggensack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

E. N. Bou Ghanem· 3 shared J. M. Leong· 2 shared M. Bhalla· 2 shared N. Siwapornchai· 2 shared A. Abamonte· 1 shared A. P. Hakansson· 1 shared A. Shrestha· 1 shared A. Tai· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

E. N. Bou Ghanem

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Author profile →

3 papers

Recent·Most cited

A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age

B. J. Joma, N. Siwapornchai, V. K. Vanguri, A. Shrestha, S. E. Roggensack, B. A. Davidson, A. Tai, A. P. Hakansson, S. N. Meydani, J. M. Leong, E. N. Bou Ghanem

This paper develops a murine model showing that viral infection and aging enhance Streptococcus pneumoniae pathogenicity through altered bacterial behavior, neutrophil dysfunction, and increased lung bacterial growth.

bioRxiv · Jul 29, 2020Microbiology

Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill S. pneumoniae

M. Bhalla, S. R. Simmons, A. Abamonte, S. E. Herring, S. E. Roggensack, E. N. Bou Ghanem

This study shows that adenosine signaling through A1 receptors improves neutrophil function in aged mice, reversing their reduced ability to kill pneumococcus.

bioRxiv · Apr 14, 2020Immunology

Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production

N. Siwapornchai, J. N. Lee, E. Y. I. Tchalla, M. Bhalla, J. Hui Yeoh, S. E. Roggensack, J. M. Leong, E. N. Bou Ghanem

The paper shows that extracellular adenosine, produced via CD73, enhances PMN killing of Streptococcus pneumoniae by inhibiting IL-10 production.

bioRxiv · Dec 8, 2019Immunology