E. N. Bou Ghanem

This study evaluates a novel LEPS vaccine platform, showing it effectively protects aged mice against pneumococcal infections, with comparable antibody responses and improved function compared to Prevnar-13.

This study identifies CD73 and age-related transcriptional changes in neutrophils during Streptococcus pneumoniae infection, showing reduced immune responses and impaired bacterial killing in aged and CD73-deficient mice.

This paper develops a murine model showing that viral infection and aging enhance Streptococcus pneumoniae pathogenicity through altered bacterial behavior, neutrophil dysfunction, and increased lung bacterial growth.

This study shows that adenosine signaling through A1 receptors improves neutrophil function in aged mice, reversing their reduced ability to kill pneumococcus.

This study shows that neutrophils are necessary during pneumococcal conjugate vaccination to generate protective antibodies and host defense against infection.

The paper shows that extracellular adenosine, produced via CD73, enhances PMN killing of Streptococcus pneumoniae by inhibiting IL-10 production.

This study identifies PepN, a cell wall protein of Streptococcus pneumoniae, as a substrate of neutrophil elastase that contributes to neutrophil-mediated killing of the bacterium.