Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.
F. Flores-Santibanez, S. Rennen, D. Fernandez, C. De Nolf, S. Gaete, C. Fuentes, C. Moreno, D. Figueroa, A. Lladser, T. Iwawaki, M. R. Bono, S. Janssens, F. Osorio
This study shows that IRE1 RNase activity in tumor-associated dendritic cells regulates antitumor immunity, with XBP1s deficiency leading to increased tumor growth and impaired T cell responses.
bioRxiv · Jul 20, 2022 · PreprintImmunology