T. Iwawaki

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle

This study shows that the IRE1α/XBP1 signaling pathway promotes myoblast fusion in skeletal muscle by upregulating profusion genes like Myomaker, crucial for muscle regeneration.

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Neutrophilic Airway Inflammation

This study shows that unconventional IRE1 activation enhances TH17 responses and neutrophilic airway inflammation in fungal asthma.

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.

This study shows that IRE1 RNase activity in tumor-associated dendritic cells regulates antitumor immunity, with XBP1s deficiency leading to increased tumor growth and impaired T cell responses.

The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

This study shows that the IRE1/XBP1 signaling pathway enhances skeletal muscle regeneration by boosting satellite cell proliferation in a cell non-autonomous way.

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

This study shows that deleting XBP1 in hepatocytes causes liver injury in mice, which is due to excessive IRE1 activation rather than XBP1 loss itself.

IRE1? regulates macrophage polarization, PD-L1 expression and tumor survival

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.