Author

S. Riesebosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Z. Mykytyn· 3 shared B. L. Haagmans· 3 shared D. Schipper· 3 shared M. M. Lamers· 3 shared T. I. Breugem· 3 shared P. B. van den Doel· 2 shared D. C. Wu· 1 shared E. Cuppen· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

A. Z. Mykytyn

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, Y. Wang, D. C. Wu, S. Riesebosch, P. B. van den Doel, D. Schipper, T. Bestebroer, N. C. Wu, B. L. Haagmans

The paper shows that using human airway cells prevents SARS-CoV-2 from mutating its multibasic cleavage site during propagation.

bioRxiv · Jan 22, 2021Microbiology

The SARS-CoV-2 multibasic cleavage site facilitates early serine protease-mediated entry into organoid-derived human airway cells

A. Z. Mykytyn, T. I. Breugem, S. Riesebosch, D. Schipper, P. B. van den Doel, R. Rottier, M. M. Lamers, B. L. Haagmans

This study shows that the SARS-CoV-2 spike protein's multibasic cleavage site enhances entry into human airway cells via serine proteases, and that blocking these proteases inhibits infection.

bioRxiv · Sep 7, 2020Microbiology

SARS-CoV-2 Productively Infects Human Gut Enterocytes

M. M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, J. Puschhof, T. I. Breugem, R. B. G. Ravelli, J. P. van Schayck, A. Z. Mykytyn, H. Q. Duimel, E. van Donselaar, S. Riesebosch, H. J. H. Kuijpers, D. Schipper, W. J. van de Wetering, , H. Clevers

The paper shows SARS-CoV-2 infects human gut enterocytes in small intestinal organoids, leading to viral replication and a strong immune response.

bioRxiv · Apr 25, 2020Cell Biology