Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
14 papers
Recent·Most cited
L. Bauer, L. Rijsbergen, L. Leijten, F. F. W. Benavides, D. Noack, M. M. Lamers, B. L. Haagmans, R. D. de Vries, R. L. de Swart, D. van Riel
This study shows that endothelial cells are abortively infected by influenza A virus and contribute to systemic inflammation through increased cytokine secretion in co-cultures with infected epithelial cells.
bioRxiv · Aug 19, 2022Microbiology
M. Rissmann, D. Noack, D. van Riel, K. S. Schmitz, R. D. de Vries, P. van Run, M. M. Lamers, C. GeurtsvanKessel, M. Koopmans, R. Fouchier, T. Kuiken, B. Haagmans, B. Rockx
This study inoculates Syrian golden hamsters with SARS-CoV-2 Omicron BA.1 to compare its pathogenicity and viral shedding to Delta, finding reduced clinical signs and viral shedding but still pneumonia, with pre-existing immunity offering protection.
bioRxiv · Mar 15, 2022Microbiology
A. Z. Mykytyn, M. Rissmann, A. Kok, M. Rosu, D. Schipper, T. I. Breugem, P. B. van den Doel, F. Chandler, T. Bestebroer, M. de Wit, M. E. van Royen, R. Molenkamp, B. Oude Munnink, R. D. de Vries, C. GeurtsvanKessel, , B. Haagmans
This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.
bioRxiv · Feb 23, 2022 · PreprintMicrobiology
W. Du, D. L. Hurdiss, D. Drabek, A. Z. Mykytyn, F. Kaiser, M. Gonzalez-Hernandez, D. Munoz-Santos, M. M. Lamers, R. van Haperen, W. Li, I. Drulyte, C. Wang, I. Sola, F. Armando, G. Beythien, , B. J. Bosch
bioRxiv · Feb 17, 2022 · PreprintMicrobiology
M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, N. Groen, K. Knoops, D. Schipper, R. van Acker, P. B. van den Doel, T. Bestebroer, C. D. Koopman, C. Reusken, M. J. Muraro, C. H. GeurtsvanKessel, M. E. van Royen, P. J. Peters, , B. L. Haagmans
This study compares the replication efficiency of SARS-CoV-2 Omicron with earlier variants in human airway and alveolar epithelial cells, finding higher replication in airways and reduced replication in alveolar type 2 cells.
bioRxiv · Jan 19, 2022 · PreprintMicrobiology
M. Chatterjee, L. Z. X. Huang, A. Z. Mykytyn, C. Wang, M. M. Lamers, B. Westendorp, R. W. Wubbolts, J. P. M. v. Putten, B. J. Bosch, B. Haagmans, K. Strijbis
This study shows that glycosylated mucin domains on respiratory epithelial cells restrict SARS-CoV-2 infection by reducing viral entry.
bioRxiv · Oct 29, 2021Microbiology
M. M. Lamers, T. I. Breugem, A. Z. Mykytyn, Y. Wang, N. Groen, K. Knoops, D. Schipper, J. van der Vaart, C. D. Koopman, J. Zhang, D. C. Wu, P. B. van den Doel, T. Bestebroer, C. C. GeurtsvanKessel, P. J. Peters, , B. L. Haagmans
The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.
bioRxiv · May 3, 2021 · PreprintMicrobiology
M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, Y. Wang, D. C. Wu, S. Riesebosch, P. B. van den Doel, D. Schipper, T. Bestebroer, N. C. Wu, B. L. Haagmans
The paper shows that using human airway cells prevents SARS-CoV-2 from mutating its multibasic cleavage site during propagation.
bioRxiv · Jan 22, 2021Microbiology
A. Z. Mykytyn, T. I. Breugem, S. Riesebosch, D. Schipper, P. B. van den Doel, R. Rottier, M. M. Lamers, B. L. Haagmans
This study shows that the SARS-CoV-2 spike protein's multibasic cleavage site enhances entry into human airway cells via serine proteases, and that blocking these proteases inhibits infection.
bioRxiv · Sep 7, 2020Microbiology
A. Z. Mykytyn, M. M. Lamers, N. M. A. Okba, T. I. Breugem, D. Schipper, P. B. van den Doel, P. van Run, G. van Amerongen, L. de Waal, M. Koopmans, K. J. Stittelaar, J. van den Brand, B. L. Haagmans
This study shows rabbits can be infected with SARS-CoV-2 and shed infectious virus from the nose and throat.
bioRxiv · Aug 27, 2020Microbiology
B. L. Haagmans, D. Noack, N. M. A. Okba, W. LI, C. Wang, T. Bestebroer, R. de Vries, S. Herfst, D. de Meulder, P. van Run, M. M. Lamers, B. Rijnders, C. Rokx, F. J. M. van Kuppeveld, F. Grosveld, , B. Rockx
This study shows that high-dose convalescent plasma or monoclonal antibodies protect hamsters from SARS-CoV-2-induced lower respiratory disease, but lower doses are ineffective.
bioRxiv · Aug 24, 2020Microbiology
M. M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, J. Puschhof, T. I. Breugem, R. B. G. Ravelli, J. P. van Schayck, A. Z. Mykytyn, H. Q. Duimel, E. van Donselaar, S. Riesebosch, H. J. H. Kuijpers, D. Schipper, W. J. van de Wetering, , H. Clevers
The paper shows SARS-CoV-2 infects human gut enterocytes in small intestinal organoids, leading to viral replication and a strong immune response.
bioRxiv · Apr 25, 2020Cell Biology
K. Bezstarosti, M. M. Lamers, W. A. Doff, P. C. Wever, K. T. Thai, J. J. van Kampen, B. L. Haagmans, J. A. Demmers
This study demonstrates that targeted mass spectrometry proteomics can detect SARS-CoV-2 proteins in clinical specimens with high sensitivity, correlating with PCR Ct values.
bioRxiv · Apr 23, 2020Biochemistry
M. Richard, A. Kok, D. de Meulder, T. M. Bestebroer, M. M. Lamers, N. M. A. Okba, M. Fentener van Vlissingen, B. Rockx, B. L. Haagmans, M. P. G. Koopmans, R. A. M. Fouchier, S. Herfst
This study shows SARS-CoV-2 spreads via direct contact and air between ferrets, supporting social distancing measures.
bioRxiv · Apr 16, 2020Microbiology