Author

K. Knoops

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Z. Mykytyn· 3 shared B. L. Haagmans· 3 shared D. Schipper· 3 shared M. M. Lamers· 3 shared P. J. Peters· 3 shared T. I. Breugem· 3 shared C. D. Koopman· 2 shared H. Clevers· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Z. Mykytyn

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

B. Klabunde, A. Wesener, W. Bertrams, I. Beinborn, N. Paczia, K. Surmann, S. Blankenburg, J. Wilhelm, J. Serrania, K. Knoops, E. M. Elsayed, K. Laakmann, A. L. Jung, A. Kirschbaum, M. Abu Mraheil, , B. Schmeck

The paper investigates how NAD+ metabolism affects bacterial respiratory infections, finding that modulating NAD+ levels impacts both host and bacterial outcomes.

bioRxiv · Apr 13, 2023Immunology

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

M. M. Lamers, A. Z. Mykytyn, T. I. Breugem, N. Groen, K. Knoops, D. Schipper, R. van Acker, P. B. van den Doel, T. Bestebroer, C. D. Koopman, C. Reusken, M. J. Muraro, C. H. GeurtsvanKessel, M. E. van Royen, P. J. Peters, , B. L. Haagmans

This study compares the replication efficiency of SARS-CoV-2 Omicron with earlier variants in human airway and alveolar epithelial cells, finding higher replication in airways and reduced replication in alveolar type 2 cells.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7

M. M. Lamers, T. I. Breugem, A. Z. Mykytyn, Y. Wang, N. Groen, K. Knoops, D. Schipper, J. van der Vaart, C. D. Koopman, J. Zhang, D. C. Wu, P. B. van den Doel, T. Bestebroer, C. C. GeurtsvanKessel, P. J. Peters, , B. L. Haagmans

The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.

bioRxiv · May 3, 2021 · PreprintMicrobiology

Exostosin-1 Glycosyltransferase Regulates Endoplasmic Reticulum Architecture and Dynamics

D. Kerselidou, B. S. Dohai, D. R. Nelson, S. Daakour, N. De Cock, D.-K. Kim, J. Olivet, D. C. El Assal, A. Jaiswal, D. Saha, C. Pain, F. Matthijssens, P. Lemaitre, M. Herfs, J. Chapuis, , J.-C. Twizere

This study shows that Exostosin-1 glycosyltransferase regulates ER morphology and dynamics, affecting cell size and metabolic processes in mammalian cells.

bioRxiv · Sep 2, 2020 · PreprintCell Biology

SARS-CoV-2 Productively Infects Human Gut Enterocytes

M. M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, J. Puschhof, T. I. Breugem, R. B. G. Ravelli, J. P. van Schayck, A. Z. Mykytyn, H. Q. Duimel, E. van Donselaar, S. Riesebosch, H. J. H. Kuijpers, D. Schipper, W. J. van de Wetering, , H. Clevers

The paper shows SARS-CoV-2 infects human gut enterocytes in small intestinal organoids, leading to viral replication and a strong immune response.

bioRxiv · Apr 25, 2020Cell Biology

High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development

X. Liu, C. Gallay, M. Kjos, A. Domenech, J. Slager, S. P. van Kessel, K. Knoops, R. A. Sorg, J.-R. Zhang, J.-W. Veening

This study uses CRISPRi to identify essential genes in S. pneumoniae, revealing roles in cell wall synthesis and competence development, and highlights potential antibiotic targets.

bioRxiv · Nov 17, 2016Microbiology