Author

J. Puschhof

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

H. Clevers· 3 shared J. Beumer· 2 shared A. C. Rios· 1 shared A. Cleven· 1 shared A. D. Meringa· 1 shared A. K. L. Wezenaar· 1 shared A. M. M. Eggermont· 1 shared A. O. Chertkova· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

H. Clevers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium

F. H. van der Linden, E. K. Mahlandt, J. J. G. Arts, J. Beumer, J. Puschhof, S. M. A. de Man, A. O. Chertkova, B. Ponsioen, H. Clevers, J. D. van Buul, M. Postma, T. W. J. Gadella, J. Goedhart

This paper introduces a new calcium biosensor based on fluorescence lifetime imaging, which provides accurate and pH-insensitive quantification of intracellular calcium concentrations.

bioRxiv · Jun 21, 2021Cell Biology

Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids

J. F. Dekkers, M. Alieva, A. Cleven, F. Keramati, P. Brazda, H. G. Rebel, A. K. L. Wezenaar, J. Puschhof, M.-B. Buchholz, M. Barrera Roman, I. Johanna, A. D. Meringa, D. Fasci, M. H. Geurts, H. C. R. Ariese, , A. C. Rios

The paper develops BEHAV3D, a 3D imaging-transcriptomics platform to study T cell behavior and molecular mechanisms in cancer organoids, identifying a super engager cluster with unique gene signatures and IFN-I priming capabilities.

bioRxiv · May 5, 2021Cancer Biology

SARS-CoV-2 Productively Infects Human Gut Enterocytes

M. M. Lamers, J. Beumer, J. van der Vaart, K. Knoops, J. Puschhof, T. I. Breugem, R. B. G. Ravelli, J. P. van Schayck, A. Z. Mykytyn, H. Q. Duimel, E. van Donselaar, S. Riesebosch, H. J. H. Kuijpers, D. Schipper, W. J. van de Wetering, , H. Clevers

The paper shows SARS-CoV-2 infects human gut enterocytes in small intestinal organoids, leading to viral replication and a strong immune response.

bioRxiv · Apr 25, 2020Cell Biology