Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
S. S. Chopra, A. Jenney, A. Palmer, M. Niepel, M. Chung, C. Mills, S. C. Sivakumaren, Q. Liu, J.-Y. Chen, C. Yapp, J. Asara, N. S. Gray, P. K. Sorger
The paper shows that combining mTOR and PIKK inhibitors kills triple-negative breast cancer cells by exploiting replication and checkpoint vulnerabilities.
bioRxiv · Jul 12, 2019 · PreprintCancer Biology