Author

M. Niepel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

C. Mills· 2 shared K. Kunii· 2 shared M. Chung· 2 shared P. K. Sorger· 2 shared A. D. Stern· 1 shared A. F. L. Hurlstone· 1 shared A. Jenney· 1 shared A. L. Raybuck· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

C. Mills

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

C. W. Wong, C. Evangelou, K. N. Sefton, R. Leshem, K. Sergiou, M. L. Fernandez Carro, E. Uzuner, H. Mole, B. A. Telfer, D. J. Wilcock, M. P. Smith, K. Kunii, N. R. Perl, P. Lorigan, K. J. Williams, , A. F. L. Hurlstone

This study shows that PARP14 inhibition restores PD-1 checkpoint inhibitor response in IFNγ-resistant tumors by increasing T cell infiltration and reducing regulatory T cells.

Nature Communications · Sep 26, 2023Peer-reviewedCancer Biology

Selective pharmaceutical inhibition of PARP14 mitigates allergen-induced IgE and mucus overproduction in a mouse model of pulmonary allergic response

A. M. Eddie, L. B. Schenkel, K. K. Swinger, J. R. Molina, K. Kunii, A. L. Raybuck, H. Keilhack, M. Niepel, R. S. Peebles, M. R. Boothby, S. H. Cho

This study shows that inhibiting PARP14's catalytic activity reduces allergen-induced IgE and mucus overproduction in a mouse model of allergic response.

ImmunoHorizons · Jul 1, 2022Peer-reviewedImmunology

Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

S. S. Chopra, A. Jenney, A. Palmer, M. Niepel, M. Chung, C. Mills, S. C. Sivakumaren, Q. Liu, J.-Y. Chen, C. Yapp, J. Asara, N. S. Gray, P. K. Sorger

The paper shows that combining mTOR and PIKK inhibitors kills triple-negative breast cancer cells by exploiting replication and checkpoint vulnerabilities.

bioRxiv · Jul 12, 2019 · PreprintCancer Biology

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

M. Niepel, M. Hafner, C. Mills, K. Subramanian, E. H. Williams, M. Chung, B. Gaudio, A. M. Barrette, A. D. Stern, B. Hu, J. E. Korkola, LINCS Consortium, J. W. Gray, M. R. Birtwistle, L. M. Heiser, P. K. Sorger

This study investigates factors affecting the reproducibility of in vitro drug-response assays across multiple centers, identifying context-sensitive factors that impact results.

bioRxiv · Feb 5, 2019 · PreprintCancer Biology