C. Mills

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon

This study shows that Smad4 loss in the mouse intestinal epithelium reduces pathological fibrosis and improves mucosal repair after DSS-induced injury.

Systematic Engineering of Virus-Like Particles to Identify Self-Assembly Rules for Shifting Particle Size

The paper systematically engineers virus-like particles to identify self-assembly rules that control particle size by mutating key residues in coat proteins and analyzing the effects.

A cross-sectional study of the commercial plant-based landscape across the US, UK and Canada.

This study analyzes the nutritional content of commercial plant-based products across the US, UK, and Canada, finding they are generally lower in saturated fat and sodium than meat-based options but require improvement.

Proteomic profiling of breast cancer cell lines and models

The paper performs proteomic profiling of 61 breast cancer cell lines, identifies molecular subtypes, and makes datasets publicly available for drug response prediction and therapeutic marker discovery.

Inhibition of Wnt signalling by Notch via two distinct mechanisms

The paper identifies two distinct mechanisms by which Notch inhibits Wnt signaling by limiting β-catenin transcriptional activity in vertebrate cells.

Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

The paper shows that combining mTOR and PIKK inhibitors kills triple-negative breast cancer cells by exploiting replication and checkpoint vulnerabilities.

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

This study investigates factors affecting the reproducibility of in vitro drug-response assays across multiple centers, identifying context-sensitive factors that impact results.