Powassan Viruses Spread Cell to Cell During Direct Isolation from IxodesTicks and Persistently Infect Human Brain Endothelial Cells and Pericytes
J. N. Conde, S. Sanchez-Vicente, N. Saladino, E. E. Gorbunova, W. R. Schutt, M. C. Mladinich, G. Himmler, J. L. Benach, H. K. Kim, E. R. Mackow
This study isolates and characterizes POWVs from ticks, showing they spread cell-to-cell in culture and infect human brain endothelial cells and pericytes, leading to persistent infection and inflammatory responses.
bioRxiv · Sep 30, 2021Microbiology