Author

M. C. Mladinich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. R. Mackow· 4 shared J. N. Conde· 4 shared W. R. Schutt· 4 shared H. K. Kim· 3 shared E. E. Gorbunova· 2 shared G. E. Himmler· 2 shared G. Himmler· 2 shared N. Saladino· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMicrobiology

E. R. Mackow

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4 papers

Recent·Most cited

Age-dependent Powassan Virus Lethality is Directed by Glial Cell Activation and Divergent Neuroinflammatory Cytokine Responses in a Murine Model

M. C. Mladinich, G. Himmler, J. N. Conde, E. Gorbunova, W. R. Schutt, S. Sarkar, S.-A. Tsirka, H. K. Kim, E. R. Mackow

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

ZIKV Induction of Tristetraprolin in Endothelial and Sertoli Cells Post-Transcriptionally Inhibits IFNβ/{lambda} Expression and Promotes ZIKV Persistence

W. R. Schutt, J. N. Conde, M. C. Mladinich, G. E. Himmler, E. R. Mackow

This study shows ZIKV induces TTP in endothelial and Sertoli cells, which post-transcriptionally inhibits IFNβ/λ secretion, promoting viral persistence.

bioRxiv · May 3, 2023Microbiology

Establishment of a CPER Reverse Genetics System for Powassan Virus Defines Attenuating NS1 Glycosylation Sites and an Infectious NS1-GFP11 Reporter Virus

J. N. Conde, G. E. Himmler, M. C. Mladinich, Y. X. Setoh, A. A. Amarilla, W. R. Schutt, N. Saladino, E. E. Gorbunova, D. J. Salamango, E. Wimmer, H. K. Kim, E. R. Mackow

This paper establishes a reverse genetics system for Powassan virus, identifies attenuating NS1 glycosylation sites, and creates an infectious NS1-GFP11 reporter virus to study viral functions.

bioRxiv · May 3, 2023Microbiology

Powassan Viruses Spread Cell to Cell During Direct Isolation from IxodesTicks and Persistently Infect Human Brain Endothelial Cells and Pericytes

J. N. Conde, S. Sanchez-Vicente, N. Saladino, E. E. Gorbunova, W. R. Schutt, M. C. Mladinich, G. Himmler, J. L. Benach, H. K. Kim, E. R. Mackow

This study isolates and characterizes POWVs from ticks, showing they spread cell-to-cell in culture and infect human brain endothelial cells and pericytes, leading to persistent infection and inflammatory responses.

bioRxiv · Sep 30, 2021Microbiology