Author

H. K. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

E. R. Mackow· 4 shared J. N. Conde· 4 shared W. R. Schutt· 4 shared G. Himmler· 3 shared M. C. Mladinich· 3 shared E. E. Gorbunova· 2 shared E. Gorbunova· 2 shared N. Saladino· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

E. R. Mackow

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Age-dependent Powassan Virus Lethality is Directed by Glial Cell Activation and Divergent Neuroinflammatory Cytokine Responses in a Murine Model

M. C. Mladinich, G. Himmler, J. N. Conde, E. Gorbunova, W. R. Schutt, S. Sarkar, S.-A. Tsirka, H. K. Kim, E. R. Mackow

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Live Malassezia strains isolated from the mucosa of patients with ulcerative colitis

Y.-J. Cho, J. Yang, S. Y. Shin, H. K. Kim, P. Rintarhat, M. Park, M. Sung, K. Lagree, D. Underhill, D.-W. Lee, C. H. Choi, C.-S. Yang, W. H. Jung

This study isolates and characterizes live Malassezia globosa strains from ulcerative colitis patients' intestinal mucosa, showing they exacerbate colitis in mice and exhibit hypoxia adaptation.

bioRxiv · Nov 28, 2023 · PreprintMicrobiology

Age-dependent Powassan Virus Lethality and Neuropathogenesis in Mice

M. Mladinich, G. Himmler, J. N. Conde, E. Gorbunova, W. R. Schutt, S. Tsirka, H. K. Kim, E. R. Mackow

This study shows that older mice are more susceptible to lethal Powassan virus infection, with increased viral load and severe brain damage compared to younger mice.

bioRxiv · May 11, 2023 · PreprintMicrobiology

Establishment of a CPER Reverse Genetics System for Powassan Virus Defines Attenuating NS1 Glycosylation Sites and an Infectious NS1-GFP11 Reporter Virus

J. N. Conde, G. E. Himmler, M. C. Mladinich, Y. X. Setoh, A. A. Amarilla, W. R. Schutt, N. Saladino, E. E. Gorbunova, D. J. Salamango, E. Wimmer, H. K. Kim, E. R. Mackow

This paper establishes a reverse genetics system for Powassan virus, identifies attenuating NS1 glycosylation sites, and creates an infectious NS1-GFP11 reporter virus to study viral functions.

bioRxiv · May 3, 2023Microbiology

Powassan Viruses Spread Cell to Cell During Direct Isolation from IxodesTicks and Persistently Infect Human Brain Endothelial Cells and Pericytes

J. N. Conde, S. Sanchez-Vicente, N. Saladino, E. E. Gorbunova, W. R. Schutt, M. C. Mladinich, G. Himmler, J. L. Benach, H. K. Kim, E. R. Mackow

This study isolates and characterizes POWVs from ticks, showing they spread cell-to-cell in culture and infect human brain endothelial cells and pericytes, leading to persistent infection and inflammatory responses.

bioRxiv · Sep 30, 2021Microbiology

A Protein A based Staphylococcus aureus vaccine with improved safety

M. Shi, X. Chen, Y. Sun, H. K. Kim, O. Schneewind, D. M. Missiakas

The paper identifies safer variants of Staphylococcal protein A (SpA) to develop clinical-grade vaccines for S. aureus, addressing immune escape mechanisms.

bioRxiv · Feb 19, 2021Microbiology

Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection

H. K. Kim, H. Kim, M. K. Lee, W. H. Choi, Y. Jang, J. S. Shin, J.-Y. Park, K. H. Kim, H. W. Han, M. Kim, Y. C. Lim, J. Yoo

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

bioRxiv · Aug 6, 2020 · PreprintMicrobiology