Author

E. E. Gorbunova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

E. R. Mackow· 3 shared H. K. Kim· 2 shared J. N. Conde· 2 shared M. C. Mladinich· 2 shared N. Saladino· 2 shared W. R. Schutt· 2 shared A. A. Amarilla· 1 shared D. J. Salamango· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

E. R. Mackow

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Establishment of a CPER Reverse Genetics System for Powassan Virus Defines Attenuating NS1 Glycosylation Sites and an Infectious NS1-GFP11 Reporter Virus

J. N. Conde, G. E. Himmler, M. C. Mladinich, Y. X. Setoh, A. A. Amarilla, W. R. Schutt, N. Saladino, E. E. Gorbunova, D. J. Salamango, E. Wimmer, H. K. Kim, E. R. Mackow

This paper establishes a reverse genetics system for Powassan virus, identifies attenuating NS1 glycosylation sites, and creates an infectious NS1-GFP11 reporter virus to study viral functions.

bioRxiv · May 3, 2023Microbiology

Powassan Viruses Spread Cell to Cell During Direct Isolation from IxodesTicks and Persistently Infect Human Brain Endothelial Cells and Pericytes

J. N. Conde, S. Sanchez-Vicente, N. Saladino, E. E. Gorbunova, W. R. Schutt, M. C. Mladinich, G. Himmler, J. L. Benach, H. K. Kim, E. R. Mackow

This study isolates and characterizes POWVs from ticks, showing they spread cell-to-cell in culture and infect human brain endothelial cells and pericytes, leading to persistent infection and inflammatory responses.

bioRxiv · Sep 30, 2021Microbiology

Binding of the Andes Virus Nucleocapsid Protein to RhoGDI Induces the Release and Activation of the Permeability Factor RhoA

E. E. Gorbunova, E. R. Mackow

This study identifies how the Andes virus N protein interacts with RhoGDI to release and activate RhoA, increasing PMEC permeability and contributing to hantavirus pulmonary syndrome.

bioRxiv · Mar 5, 2021Microbiology