Membrane curvature sensing of the lipid-anchored K-Ras small GTPases
H. Liang, H. Mu, F. Jean-Francois, B. Lakshman, S. Sarkar-Banerjee, Y. Zhuang, Y. Zeng, W. Gao, D. V. Nissley, A. A. Gorfe, W. Zhao, Y. Zhou
This study shows that K-Ras and H-Ras isoforms respond differently to plasma membrane curvature, with K-Ras favoring less curved membranes and H-Ras favoring more curved membranes, mediated by phospholipid sorting.
bioRxiv · Dec 10, 2018 · PreprintBiochemistry