Author

S. Sealfon

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Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. Bukreyev· 1 shared C. Ye· 1 shared E. Zaslavsky· 1 shared F. Zhou· 1 shared G. Nudelman· 1 shared L. Martinez-Sobrido· 1 shared N. Jackson· 1 shared P. Ilinykh· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

A. Bukreyev

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1 paper

Recent·Most cited

Multiple layers of innate immune response antagonism of SARS-CoV-2

F. Zhou, S. Periasamy, N. Jackson, W. S. Cheng, R. Soto Acosta, P. Ilinykh, C. Ye, S. Chauhan, G. Nudelman, E. Zaslavsky, S. Widen, L. Martinez-Sobrido, S. Sealfon, A. Bukreyev

This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.

bioRxiv · Jan 29, 2024 · PreprintMicrobiology