Author

S. Widen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Bukreyev· 1 shared A. Tamin· 1 shared A. Uehara· 1 shared B. B. Rasmussen· 1 shared B. Lynch· 1 shared B. Whitaker· 1 shared C. Goldsmith· 1 shared C. Paden· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Bukreyev

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multiple layers of innate immune response antagonism of SARS-CoV-2

F. Zhou, S. Periasamy, N. Jackson, W. S. Cheng, R. Soto Acosta, P. Ilinykh, C. Ye, S. Chauhan, G. Nudelman, E. Zaslavsky, S. Widen, L. Martinez-Sobrido, S. Sealfon, A. Bukreyev

This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.

bioRxiv · Jan 29, 2024 · PreprintMicrobiology

Skeletal Muscle Transcriptome Alterations Related to Physical Function Decline in Older Mice

T. G. Graber, R. Maroto, J. Thompson, S. Widen, Z. Man, M. L. Pajski, B. B. Rasmussen

This study identifies age-related transcriptomic changes in skeletal muscle of older mice that correlate with declines in physical function.

bioRxiv · May 17, 2021Physiology

Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

J. Harcourt, A. Tamin, X. Lu, S. Kamili, S. Kumar Sakthivel, L. Wang, J. Murray, K. Queen, B. Lynch, B. Whitaker, Y. Tao, C. Paden, J. Zhang, Y. Li, A. Uehara, , N. J. Thornburg

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology