Author

W. S. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. Bukreyev· 2 shared E. Zaslavsky· 2 shared S. Periasamy· 2 shared A. B. Rubenstein· 1 shared A. Carfi· 1 shared A. Woods· 1 shared B. M. Nagata· 1 shared B. S. Graham· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Bukreyev

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Author profile →

2 papers

Recent·Most cited

Multiple layers of innate immune response antagonism of SARS-CoV-2

F. Zhou, S. Periasamy, N. Jackson, W. S. Cheng, R. Soto Acosta, P. Ilinykh, C. Ye, S. Chauhan, G. Nudelman, E. Zaslavsky, S. Widen, L. Martinez-Sobrido, S. Sealfon, A. Bukreyev

This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.

bioRxiv · Jan 29, 2024 · PreprintMicrobiology

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

M. Meyer, Y. Wang, D. Edwards, G. R. Smith, A. B. Rubenstein, P. Ramanathan, C. E. Mire, C. Pietzsch, X. Chen, Y. Ge, W. S. Cheng, C. Henry, A. Woods, L. Ma, G. B. E. Stewart-Jones, , A. Bukreyev

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

bioRxiv · Jan 25, 2021 · PreprintImmunology