The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
C. Heissenberger, T. L. Krammer, J. A. Rollins, F. Nagelreiter, I. Stocker, L. Wacheul, A. Shpylovyi, S. Snow, J. Grillari, A. Rogers, D. L. Lafontaine, M. Schosserer
This study identifies NSUN-1 as an enzyme that methylates rRNA at position C2982 in C. elegans, showing that its depletion affects healthspan, oogenesis, and cuticle integrity.
bioRxiv · Mar 16, 2020Cell Biology