S. Stutzmann

Molecular mechanism of plasmid elimination by the DdmDE defense system

This study uses cryo-EM to elucidate the mechanism of plasmid elimination by the DdmDE defense system in Vibrio cholerae.

A single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

This study identifies a SNP in V. cholerae that determines whether the T6SS is constitutive or inducible, independent of known regulators.

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

This study shows that Vibrio cholerae uses type VI secretion system-mediated neighbor predation to acquire large DNA fragments (>150 kbp) from non-kin bacteria, facilitating significant horizontal gene transfer.

DNA-uptake pilus of Vibrio cholerae capable of kin-discriminated auto-aggregation

This study shows that DNA-uptake pili in Vibrio cholerae mediate kin-discriminated auto-aggregation and inter-bacterial interactions during surface colonization.

QstR-dependent regulation of natural competence and type VI secretion in Vibrio cholerae

This study identifies the QstR regulon in Vibrio cholerae and shows QstR functions as a dual transcription factor independent of c-di-GMP, regulating natural competence and type VI secretion.

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

This study identifies molecular mechanisms enabling Vibrio cholerae to replicate within amoebae and escape, highlighting the role of minor virulence factors in its aquatic survival.