The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63
P. A. Sandoz, R. A. Denhardt-Eriksson, L. Abrami, L. Abriata, G. Spreemann, C. Maclachlan, S. Ho, B. Kunz, K. Hess, G. W. Knott, V. Hatzimanikatis, F. G. van der Goot
This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.
bioRxiv · Oct 1, 2018 · PreprintCell Biology