FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.
K. Yamawaki, I. Shiina, T. Murata, S. Tateyama, Y. Maekawa, M. Niwa, M. Shimonaka, K. Okamoto, T. Suzuki, T. Nishida, R. Abe, Y. Obata
This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.
bioRxiv · Jan 1, 2021 · PreprintCancer Biology