Author

I. Shiina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. Abe· 3 shared T. Nishida· 3 shared Y. Obata· 3 shared M. Natsume· 2 shared M. Niwa· 2 shared M. Shimonaka· 2 shared T. Murata· 2 shared A. Nakano· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

R. Abe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5

M. Natsume, M. Niwa, S. Ichikawa, T. Okamoto, H. Tsutsui, D. Usukura, T. Murata, R. Abe, M. Shimonaka, T. Nishida, I. Shiina, Y. Obata

This study shows that BFA and M-COPA inhibit RTK export from the ER by inactivating ARF1, ARF4, and ARF5, leading to cancer cell apoptosis.

bioRxiv · Oct 11, 2023Cell Biology

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

Y. Obata, K. Kurokawa, T. Tojima, M. Natsume, I. Shiina, T. Takahashi, R. Abe, A. Nakano, T. Nishida

This study identifies the molecular mechanisms by which mutant KIT remains in the Golgi and activates oncogenic signaling in GIST cells.

bioRxiv · Dec 19, 2022 · PreprintCancer Biology

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

K. Yamawaki, I. Shiina, T. Murata, S. Tateyama, Y. Maekawa, M. Niwa, M. Shimonaka, K. Okamoto, T. Suzuki, T. Nishida, R. Abe, Y. Obata

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

bioRxiv · Jan 1, 2021 · PreprintCancer Biology