M. Niwa

Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5

This study shows that BFA and M-COPA inhibit RTK export from the ER by inactivating ARF1, ARF4, and ARF5, leading to cancer cell apoptosis.

Iron regulates contrasting toxicity of uropathogenic Eschericia coli in macrophages and epithelial cells.

This study compares the virulence mechanisms of four UPEC strains in macrophages and epithelial cells, showing that iron availability regulates their contrasting toxicities.

A Role for Nup153 in Nuclear Assembly Reveals Differential Requirements for Targeting of Nuclear Envelope Constituents

This study identifies Nup153's role in nuclear envelope formation, showing differential requirements for targeting of nuclear envelope proteins during nuclear reassembly.

Anterior insula-associated social novelty recognition: orchestrated regulation by a local retinoic acid cascade and oxytocin signaling

This study investigates the role of the anterior insula in social novelty recognition, showing its regulation by a local retinoic acid cascade and oxytocin signaling through a non-classical pathway.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

Cell-cell adhesion in plant grafting is facilitated by β-1,4-glucanases

This study identifies β-1,4-glucanases as facilitators of cell-cell adhesion in plant grafting, showing their role in promoting compatibility across species.

Transfer of Septin Rings to Cytokinetic Remnants Directs Age-Sensitive ER stress Surveillance Cell Cycle Re-entry