Activation of intestinal immunity by pathogen effector-triggered aggregation of lysosomal TIR-1/SARM1
S. Tse-Kang, K. A. Wani, N. D. Peterson, A. Page, R. Pukkila-Worley
The paper identifies lysosomal TIR-1/SARM1 as a sensor for oxidative stress induced by pathogenic bacteria, activating intestinal immunity in C. elegans.
bioRxiv · Dec 4, 2023 · PreprintImmunology