Author

K. A. Wani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. E. Irazoqui· 2 shared N. D. Peterson· 2 shared R. Pukkila-Worley· 2 shared A. Ghazi· 1 shared A. L. Page· 1 shared A. Page· 1 shared A. Wood· 1 shared C. E. Tocheny· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPhysiology

J. E. Irazoqui

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Activation of intestinal immunity by pathogen effector-triggered aggregation of lysosomal TIR-1/SARM1

S. Tse-Kang, K. A. Wani, N. D. Peterson, A. Page, R. Pukkila-Worley

The paper identifies lysosomal TIR-1/SARM1 as a sensor for oxidative stress induced by pathogenic bacteria, activating intestinal immunity in C. elegans.

bioRxiv · Dec 4, 2023 · PreprintImmunology

Glucose-fed microbiota alters intestinal epithelium and increases susceptibility to bacterial pathogens

S. F. Kingsley, Y. Seo, A. Wood, K. A. Wani, X. Gonzalez, J. E. Irazoqui, S. E. Finkel, H. A. Tissenbaum

This study shows that a glucose-fed microbiota in C. elegans reduces lifespan and healthspan, increases intestinal permeability, and raises susceptibility to bacterial pathogens.

bioRxiv · Nov 19, 2023 · PreprintPhysiology

Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans

M. A. Nasrallah, N. D. Peterson, J. E. Salisbury, P. Liu, A. L. Page, S. Y. Tse, K. A. Wani, C. E. Tocheny, R. Pukkila-Worley

The paper identifies NHR-66 as a transcriptional repressor that suppresses sphingolipid catabolism to enhance pathogen resistance in C. elegans.

bioRxiv · Aug 10, 2023 · PreprintImmunology

NHR-49/PPAR-α and HLH-30/TFEB promote C. elegans host defense via a flavin-containing monooxygenase

K. A. Wani, D. Goswamy, S. Taubert, R. Ratnappan, A. Ghazi, J. E. Irazoqui

This study identifies NHR-49/PPAR-α and HLH-30/TFEB as regulators of an infection-specific host response in C. elegans, revealing FMOs as innate immunity effectors.

bioRxiv · Sep 3, 2020Microbiology