Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
J. Zephyr, D. N. Rao, S. V. Vo, M. Henes, K. Kosovrasti, A. N. Matthew, A. K. Hedger, J. Timm, E. T. Chan, A. Ali, N. K. Yilmaz, C. A. Schiffer
The paper investigates how fluorination of HCV protease inhibitors improves resistance to the D168A variant by enabling alternate binding conformations through co-crystal structure analysis.
Journal of Molecular Biology · May 1, 2022Peer-reviewedBiochemistry