Author

E. T. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Ali· 1 shared A. K. Hedger· 1 shared A. N. Matthew· 1 shared B. Cakir· 1 shared C. A. Schiffer· 1 shared C. Kural· 1 shared D. N. Rao· 1 shared H. Qian· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Ali

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mechano-inhibition of Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis

M. Kural, U. Djakbarova, B. Cakir, Y. Tanaka, Y. Madraki, E. T. Chan, V. Arteaga Muniz, H. Qian, J. Park, L. Sewanan, I.-H. Park, L. Niklason, C. Kural

The paper shows that inhibiting endocytosis with fasudil increases Fas microaggregate formation, making cancer cells more sensitive to FasL-induced apoptosis.

bioRxiv · Jun 14, 2022 · PreprintCancer Biology

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

J. Zephyr, D. N. Rao, S. V. Vo, M. Henes, K. Kosovrasti, A. N. Matthew, A. K. Hedger, J. Timm, E. T. Chan, A. Ali, N. K. Yilmaz, C. A. Schiffer

The paper investigates how fluorination of HCV protease inhibitors improves resistance to the D168A variant by enabling alternate binding conformations through co-crystal structure analysis.

Journal of Molecular Biology · May 1, 2022Peer-reviewedBiochemistry