Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
G. Tax, K. P. Guay, T. Solde, C. J. Hitchman, J. C. Hill, S. Vasilievic, A. Lia, C. P. Modenutti, K. R. Straatman, M. Molinari, A. Santino, D. N. Hebert, N. Zitzmann, P. Roversi, M. Trerotola
This study shows that knocking out UGGT1 or UGGT1/2 genes rescues secretion of a misfolded Trop-2 glycoprotein mutant in mammalian cells.
bioRxiv · May 30, 2023 · PreprintCell Biology