Author

J. C. Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Lia· 3 shared A. Santino· 3 shared C. P. Modenutti· 3 shared N. Zitzmann· 3 shared P. Roversi· 3 shared A. V. Chandran· 2 shared D. N. Hebert· 2 shared G. Tax· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

A. Lia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

G. Tax, K. P. Guay, T. Solde, C. J. Hitchman, J. C. Hill, S. Vasilievic, A. Lia, C. P. Modenutti, K. R. Straatman, M. Molinari, A. Santino, D. N. Hebert, N. Zitzmann, P. Roversi, M. Trerotola

This study shows that knocking out UGGT1 or UGGT1/2 genes rescues secretion of a misfolded Trop-2 glycoprotein mutant in mammalian cells.

bioRxiv · May 30, 2023 · PreprintCell Biology

Fiber Diameter and Architecture Direct Three-Dimensional Assembly of Pericytes into Spheroids

S. Sharma, J. C. Hill, J. A. Phillippi, A. S. Nain

This study shows that fiber diameter and architecture influence the 3D assembly and dynamics of human pericyte spheroids, revealing their role in vascular formation and angiogenesis.

bioRxiv · Aug 2, 2022 · PreprintBioengineering

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

K. P. Guay, R. Ibba, J. L. Kiappes, M. De Benedictis, I. Zeni, J. D. Le Cornu, M. Hensen, A. V. Chandran, A. L. Kantsadi, A. T. Caputo, J. I. Blanco Capurro, Y. Bayo, J. C. Hill, K. Hudson, A. Lia, , P. Roversi

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

bioRxiv · Jun 21, 2022Biochemistry

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP glucose:glycoprotein glucosyl-transferase.

C. P. Modenutti, J. I. Blanco Capurro, R. Ibba, S. Vasiljevic, M. Hensen, D. S. Alonzi, A. V. Chandran, J. C. Hill, J. Rushton, A. Kumar, S. Rubichi, A. Lia, G. Tax, L. Marti, A. Santino, , P. Roversi

This study uses molecular dynamics simulations and structural analysis to characterize inter-domain motions in UGGT, revealing conformational flexibility and a proposed Parodi limit for substrate recognition.

bioRxiv · Dec 25, 2019Biochemistry