Author

A. Santino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

P. Roversi· 4 shared A. Lia· 3 shared C. P. Modenutti· 3 shared J. C. Hill· 3 shared N. Zitzmann· 3 shared A. V. Chandran· 2 shared D. N. Hebert· 2 shared G. Tax· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

P. Roversi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

G. Tax, K. P. Guay, T. Solde, C. J. Hitchman, J. C. Hill, S. Vasilievic, A. Lia, C. P. Modenutti, K. R. Straatman, M. Molinari, A. Santino, D. N. Hebert, N. Zitzmann, P. Roversi, M. Trerotola

This study shows that knocking out UGGT1 or UGGT1/2 genes rescues secretion of a misfolded Trop-2 glycoprotein mutant in mammalian cells.

bioRxiv · May 30, 2023 · PreprintCell Biology

Cadmium treatment induces endoplasmic reticulum stress and unfolded protein response in Arabidopsis thaliana

M. De Benedictis, A. Gallo, D. Migoni, P. Papadia, P. Roversi, A. Santino

This study shows Cd2+ stress in Arabidopsis activates ER stress and UPR via bZIP60, leading to PCD, and identifies UPR defects as a strategy for phytoremediation.

bioRxiv · Sep 23, 2022Plant Biology

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

K. P. Guay, R. Ibba, J. L. Kiappes, M. De Benedictis, I. Zeni, J. D. Le Cornu, M. Hensen, A. V. Chandran, A. L. Kantsadi, A. T. Caputo, J. I. Blanco Capurro, Y. Bayo, J. C. Hill, K. Hudson, A. Lia, , P. Roversi

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

bioRxiv · Jun 21, 2022Biochemistry

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP glucose:glycoprotein glucosyl-transferase.

C. P. Modenutti, J. I. Blanco Capurro, R. Ibba, S. Vasiljevic, M. Hensen, D. S. Alonzi, A. V. Chandran, J. C. Hill, J. Rushton, A. Kumar, S. Rubichi, A. Lia, G. Tax, L. Marti, A. Santino, , P. Roversi

This study uses molecular dynamics simulations and structural analysis to characterize inter-domain motions in UGGT, revealing conformational flexibility and a proposed Parodi limit for substrate recognition.

bioRxiv · Dec 25, 2019Biochemistry