Cancer BiologybioRxivPreprint
Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis
J. K. Lim, F. Stoelting, D. Roth…·G. Leprivier
This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.
DOI 10.1101/2024.01.27.577524