Author

J. K. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 8 Research Focus:host-pathogen & immune response· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

B. Lee· 3 shared J. A. Acklin· 3 shared S. Ikegame· 3 shared S. Kowdle· 3 shared A. R. Patel· 2 shared B. K. Chen· 2 shared B. Rotblat· 2 shared B. Tweel· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

B. Lee

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Author profile →

10 papers

Recent·Most cited

Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis

J. K. Lim, F. Stoelting, D. Roth, C. Ballmeyer, S. Tishina, L. Thewes, S. Kalis, S. Boussettaoui, D. Picard, H.-F. Zhang, O. Lewandowska, T. Reiff, T. Levy, B. Rotblat, M. Remke, , G. Leprivier

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

bioRxiv · Jan 27, 2024 · PreprintCancer Biology

Immunological landscape of human lymphoid explants during measles virus infection

J. A. Acklin, A. R. Patel, A. P. Kurland, S. Horiuchi, A. S. Moss, E. J. Degrace, S. Ikegame, J. Carmichael, S. Kowdle, P. Thibault, N. Imai, H. Ueno, B. Tweel, J. R. Johnson, B. R. Rosenberg, , J. K. Lim

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

bioRxiv · Sep 12, 2022Immunology

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

T. Levy, K. Voeltzke, L. Hauffe, K. Alasad, M. Snaebjornsson, R. Marciano, K. Scharov, M. Planque, K. Vriens, S. Christen, C. M. Funk, C. Hassiepen, A. Kahler, B. Heider, D. Picard, , G. Leprivier

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

bioRxiv · Sep 9, 2022 · PreprintCell Biology

Assessing the zoonotic potential of a novel bat morbillivirus

S. Ikegame, J. C. Carmichael, H. Wells, R. L. Furler O'Brien, J. A. Acklin, H.-P. Chiu, K. Y. Oguntuyo, R. M. Cox, A. R. Patel, S. Kowdle, C. S. Stevens, M. Eckley, S. Zhan, J. K. Lim, E. C. Veit, , B. Lee

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

bioRxiv · Sep 17, 2021 · PreprintMicrobiology

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

C. S. Stevens, K. Y. Oguntuyo, S. Kowdle, A. Gowlikar, M. N. Siddiquey, J. A. Acklin, G. Haas, R. M. Schilke, M. D. Woolard, H. Zhang, L. Brambilla, S. Ikegame, C.-t. Hung, J. K. Lim, R. W. Cross, , B. Lee

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

Passenger mutations confound phenotypes of SARM1-deficient mice

M. B. Uccellini, S. Bardina, M. T. Sanchez-Aparicio, K. M. White, Y.-J. Hou, J. K. Lim, A. Garcia-Sastre

This study shows that phenotypes in SARM1-deficient mice may be due to genetic differences between B6 and 129 backgrounds rather than SARM1 itself.

Cell Reports · Apr 1, 2020Peer-reviewedMicrobiology

Impact of Direct Acting Antivirals on Survival in Patients with Chronic Hepatitis C and Hepatocellular Carcinoma

W. M. Kamp, C. M. Sellers, S. M. Stein, J. K. Lim, H. S. Kim

This study shows that direct-acting antivirals (DAAs) and achieving SVR12 improve survival in HCV-positive patients with hepatocellular carcinoma.

bioRxiv · Mar 12, 2019Immunology

The antiparasitic drug atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides.

A. Cifuentes Kottkamp, E. De Jesus, R. Grande, J. K. Brown, A. R. Jacobs, J. K. Lim, K. Stapleford

This paper shows atovaquone inhibits arbovirus replication by depleting intracellular nucleotides and reduces ZIKV infection in human placental tissue.

bioRxiv · Dec 27, 2018Microbiology

P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model

A. Y. Soare, N. Durham, R. Gopal, B. Tweel, K. W. Hoffman, J. A. Brown, M. O'Brien, N. Bhardwaj, J. K. Lim, B. K. Chen, T. H. Swartz

bioRxiv · Jul 10, 2018Immunology

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

M. Uzzan, M. Tokuyama, A. K. Rosenstein, C. Tomescu, I. N. SahBandar, H. M. Ko, L. Leyre, A. Chokola, E. Kaplan-Lewis, G. Rodriguez, A. Seki, M. J. Corley, J. Aberg, A. La Porte, E.-y. Park, , S. Mehandru

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.

bioRxiv · Jun 14, 2018Immunology