G. Leprivier

The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma

This study shows that EIF4EBP1 is upregulated by MYC in medulloblastoma and linked to poorer patient survival.

Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma

This study shows EIF4EBP1 is upregulated by MYCN and linked to poor prognosis in neuroblastoma, with high expression associated with reduced survival and unfavorable histology.