Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis
D. Su, W. Wang, Y. Hou, L. Wang, Y. Wang, C. Yang, B. Liu, X. Chen, X. Wu, J. Wu, D. Yan, S. Wei, L. Han, S. Liu, L. Shi, L. Shan
This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.
bioRxiv · May 18, 2019 · PreprintCell Biology