T. Xie

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

Plug-and-play protein biosensors using aptamer-regulated in vitro transcription

The paper develops a modular biosensing platform using aptamer-regulated transcription to detect proteins with tunable detection ranges and diverse output responses.

ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cord using micropatterned human pluripotent stem cells

This study demonstrates that micropatterned human pluripotent stem cells self-organize into distinct midbrain and hindbrain/spinal cord regions, revealing a novel regulatory mechanism for AP patterning.

Droplet-based microfluidics as a media optimization tool for cyanobacteria

This study uses droplet-based microfluidics to optimize cyanobacterial cultivation parameters, showing that nitrate and phosphate can be limiting and demonstrating scalability to lab-scale systems.

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves

This study shows that corneal stromal stem cell secretome promotes scarless corneal wound healing and rescues sensory nerves by reducing inflammation, fibrosis, and complement-mediated cell death.

DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

DECONbench benchmarks deconvolution methods for quantifying tumor cell-type heterogeneity by providing datasets, tools, and performance evaluation.

KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

The paper identifies three new folds in the solute carrier superfamily, with one validated experimentally in the SLC44 family, providing insights into structure-function relationships.

Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

Directional Cell Migration Guided by a Strain Gradient

This study shows that strain gradients can drive directional cell migration in rat embryonic fibroblasts, distinct from durotaxis or haptotaxis.

Stem cell-free therapy for glaucoma to preserve vision

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

Variable Induction of Pro-inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

This study shows that commercial SARS CoV-2 spike protein reagents vary in their ability to induce pro-inflammatory cytokines, likely due to contamination with endotoxin (LPS).

PAM-interacting domain swapping is extensively utilized in nature to evolve CRISPR-Cas9 nucleases with altered PAM specificities

The paper identifies domain swapping in Cas9 proteins as a mechanism for evolving PAM specificity, demonstrating its prevalence and utility in generating novel PAM-specific enzymes.

Structural basis of substrate recognition and translocation by human ABCA4

This study presents cryo-EM structures of human ABCA4 in different states, revealing substrate recognition and translocation mechanisms.

A Facile and Rapid Route to Self-Digitization of Samples into a High Density Microwell Array for Digital Bioassays

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

Production of SARS-CoV-2 virus-like particles in insect cells

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

Identification and validation of a ferroptosis-related genes based prognostic signature for prostate cancer

The paper constructs and validates a prognostic signature for prostate cancer using ferroptosis-related genes, showing its association with clinical outcomes and therapeutic response.

Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis

The paper identifies a zinc metabolic defect in alveolar progenitor cells in IPF and aged mice, linked to impaired renewal and fibrosis through ZIP8 downregulation.

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

Condensation tendency of connected contractile tissue with planar isotropic actin network

The paper studies how rat embryonic fibroblast monolayers form radial symmetry under confinement, showing that contractility and cell-cell adhesion drive this structure.

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

Quantifying Tensile Forces at Cell-Cell Junctions with a DNA-based Fluorescent Probe

This paper introduces a DNA-based fluorescent probe, DNAMeter, to quantify intercellular tensile forces through real-time imaging and fluorescence signal activation.

Exogenous DCPTA ameliorates the soil drought effect on nitrogen metabolism in maize during the pre-female inflorescence emergence stage

This study shows that exogenous DCPTA improves maize drought tolerance by enhancing nitrogen metabolism during the pre-female inflorescence emergence stage.