MicrobiologybioRxiv
Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
L. Y. Lee, J. Zhou, P. Koszalka…·A. C. Hurt
The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.
DOI 10.1371/journal.ppat.1009527