Author

L. Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

T. Starkey· 2 shared A. Bassett· 1 shared A. C. Hurt· 1 shared A. Everest-Dass· 1 shared A. J. Lewis· 1 shared A. Siokis· 1 shared B. Clinch· 1 shared C. Woolley· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

T. Starkey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Oligomannosylation and MAN1A1 expression associate strongly with a subset of human cancer types

S. Chatterjee, R. Kawahara, J. Ugonotti, L. Y. Lee, A. Everest-Dass, M. Thaysen-Andersen

The paper identifies oligomannosylation and MAN1A1 expression as strongly associated with specific human cancers through glycomics analysis and MALDI-MS imaging.

bioRxiv · May 8, 2021 · PreprintBiochemistry

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

L. Y. Lee, J. Zhou, P. Koszalka, R. Frise, R. Farrukee, K. Baba, S. Miah, T. Shishido, M. Galiano, T. Hashimoto, S. Omoto, T. Uehara, E. Mifsud, N. Collinson, K. Kuhlbusch, , A. C. Hurt

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

bioRxiv · Sep 28, 2020Microbiology

A CRISPR Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis That Acts Through Reduced mTOR Signalling

L. Y. Lee, C. Woolley, T. Starkey, L. Freeman-Mills, A. Bassett, F. Franchini, L. M. Wang, A. J. Lewis, R. Arnold, I. Tomlinson

bioRxiv · Apr 18, 2019 · PreprintCancer Biology

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

P. Demetriou, E. Abu-Shah, S. McCuaig, V. Mayya, S. Valvo, K. Korobchevskaya, M. Friedrich, E. Mann, L. Y. Lee, T. Starkey, M. A. Kutuzov, J. Afrose, A. Siokis, Oxford IBD Cohort Investigators, M. Meyer-Hermann, , M. L. Dustin

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.

bioRxiv · Mar 29, 2019 · PreprintImmunology